Related Experiment Video
Updated: Aug 15, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Drugs on the horizon for diabesity
1Diabetes Group, Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK. c.j.bailey@aston.ac.uk
Abstract:
The coexistence of type 2 diabetes and obesity presents a complex therapeutic challenge. Future combination tablets may include agents to address diabetes and any accompanying cardiovascular risk factors. Injectable agents that improve glycemic control and facilitate weight loss have recently become available: the soluble amylin analogue pramlintide provides an adjunct to insulin therapy in type 1 and type 2 diabetes, and the incretin mimetic exenatide can enhance prandial insulin release in type 2 diabetes. Orally active inhibitors of the incretin-degrading enzyme dipeptidyl peptidase-IV, agonists of peroxisome proliferator-activated receptor (PPAR)-a and PPAR-g ("dual PPARs"), and the CB1 cannabinoid receptor inhibitor rimonabant are advanced in clinical development. Many novel antidiabetic and antiobesity compounds are emerging in preclinical development.
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