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Updated: Jul 12, 2026

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung
Published on: May 20, 2019
A novel method for selective delivery of drugs to the pulmonary arteries
Mark P Yeager1, Jeffrey A Clark, Scott B Yeager
1Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA. mark.p.yeager@hitchcock.org
Abstract:
Drug treatment of pulmonary hypertension may be limited by systemic hypotension. Selective action of a vasodilator drug in pulmonary arteries could be achieved by administering a vasodilator gas into systemic venous blood so that it dilates pulmonary arteries before immediate first-pass elimination via exhalation. This article presents in vivo data to show that a pharmacologically active gas can be delivered safely into systemic venous blood where it has a distribution pattern and physiologic effects similar to those observed when the gas is inhaled into pulmonary venous (systemic arterial) blood. This is a first step toward development of first-pass pulmonary clearance as a mechanism to concentrate drugs in pulmonary arteries.
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