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Small-for-gestational-age infants need dietary quality more than quantity for their development: the role of human
1Department of Paediatrics, University of Milan, San Paolo Hospital, 8 Via A. di Rudini, 20142 Milan, Italy. carlo.agostoni@unimi.it
Insights
Breastfeeding benefits infants born small for gestational age (SGA), potentially improving neurodevelopment and preventing metabolic issues. Human milk
Area of Science:
- Neonatal development
- Pediatric nutrition
- Growth disorders
Background:
- Infants born small for gestational age (SGA) exhibit developmental delays into adolescence.
- Breastfeeding's positive impact on development is pronounced in SGA infants, especially with prolonged duration.
- Human milk's nutritional components, like docosahexaenoic acid, may contribute to improved outcomes.
Discussion:
- SGA infants face risks for developmental delay and long-term metabolic complications.
- Breastfeeding offers crucial maternal-infant contact and vital nutrients.
- Specific milk components, such as LC-PUFAs, are essential for infant brain development.
Key Insights:
- Prolonged breastfeeding may mitigate developmental delays in SGA infants.
- Human milk composition plays a significant role in the neurodevelopment of SGA infants.
- Early nutritional interventions via breastfeeding can address growth restriction sequelae.
Outlook:
- Further research into optimizing human milk composition for SGA infants is warranted.
- Investigating the long-term metabolic benefits of breastfeeding in SGA populations is crucial.
- Developing targeted nutritional strategies for SGA infants could improve lifelong health outcomes.
Unlabelled:
Infants born small for gestational age (SGA) show some forms of developmental delay throughout paediatric age, and up to adolescence. The positive effect of breastfeeding on development, observed in most studies on healthy, term infants, seems to be further stressed in the group of SGA infants, particularly if breastfeeding is protracted. Besides the close maternal-infant contact of breastfeeding, the nutritional factors of human milk, above all long-chain polyunsaturated fatty acids, including docosahexaenoic acid, may at least partly account for the observed association.
Conclusion:
SGA infants represent a high-risk group, not only for developmental delay, but also for long-term, unfavourable metabolic consequences. Breastfeeding and human milk quality together could help to prevent some of the neurological and metabolic sequelae of being born growth retarded.
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