Small-for-gestational-age infants need dietary quality more than quantity for their development: the role of human

Carlo Agostoni1

  • 1Department of Paediatrics, University of Milan, San Paolo Hospital, 8 Via A. di Rudini, 20142 Milan, Italy. carlo.agostoni@unimi.it

Insights

Breastfeeding benefits infants born small for gestational age (SGA), potentially improving neurodevelopment and preventing metabolic issues. Human milk

Area of Science:

  • Neonatal development
  • Pediatric nutrition
  • Growth disorders

Background:

  • Infants born small for gestational age (SGA) exhibit developmental delays into adolescence.
  • Breastfeeding's positive impact on development is pronounced in SGA infants, especially with prolonged duration.
  • Human milk's nutritional components, like docosahexaenoic acid, may contribute to improved outcomes.

Discussion:

  • SGA infants face risks for developmental delay and long-term metabolic complications.
  • Breastfeeding offers crucial maternal-infant contact and vital nutrients.
  • Specific milk components, such as LC-PUFAs, are essential for infant brain development.

Key Insights:

  • Prolonged breastfeeding may mitigate developmental delays in SGA infants.
  • Human milk composition plays a significant role in the neurodevelopment of SGA infants.
  • Early nutritional interventions via breastfeeding can address growth restriction sequelae.

Outlook:

  • Further research into optimizing human milk composition for SGA infants is warranted.
  • Investigating the long-term metabolic benefits of breastfeeding in SGA populations is crucial.
  • Developing targeted nutritional strategies for SGA infants could improve lifelong health outcomes.
Abstract

Related Concept Videos

Parental Care00:55

Parental Care

Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
12.6K
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.1K
Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.5K
Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.1K
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
771
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K