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Updated: Aug 15, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Thyroid dysfunction in the offspring of mothers with autoimmune thyroid diseases
1Buda Children's Hospital, Budapest, Hungary. peter_f@hu.inter.net
Unlabelled:
An integrated three-compartment thyroid model exists during gestation: pregnancy influences thyroid function in several ways, the placenta plays an active role in TRH-thyroid and iodide transport and metabolism, and the fetus develops its own hypothalamic-pituitary-thyroid axis. This commentary reviews some basic and new data, especially in the maternal-offspring relationship in the case of maternal autoimmune thyroid diseases.
Conclusion:
The careful control of maternal autoimmune thyroid disease is essential in order to avoid pathological changes in the offspring.
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