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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
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Risk factors of primary thyroid dysfunction in early infants born to mothers with autoimmune thyroid disease

Junfen Fu1, Youjun Jiang, Li Liang

  • 1Department of Endocrinology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China. fjf68@yahoo.com.cn

Acta Paediatrica (Oslo, Norway : 1992)
|September 29, 2005
PubMed

Insights

Maternal autoimmune thyroid disease during pregnancy significantly impacts infant thyroid function. Careful management of these conditions is crucial to prevent adverse neonatal outcomes.

Area of Science:

  • Endocrinology
  • Neonatal Health
  • Immunology

Background:

  • Maternal thyroid dysfunction during pregnancy can pose risks to infant health.
  • Autoimmune thyroid diseases (AITD) like Graves' disease and Hashimoto thyroiditis are common in pregnant women.

Purpose of the Study:

  • To determine if maternal thyroid status and alterations during gestation affect infant thyroid function.
  • To identify risk factors for early infant thyroid dysfunction using logistic regression.

Main Methods:

  • A cross-sectional study involving 78 neonates born to mothers with AITD and a control group of neonates from healthy mothers.
  • Clinical and biochemical assessments of thyroid function, including antibody testing (TPOAb, TGAb, TRAb, TSAb) in mothers and infants.
  • Multiple logistic regression analysis to evaluate maternal and infant risk factors.

Main Results:

  • A high prevalence of subtle thyroid abnormalities (52.6%) was observed in infants of mothers with AITD, significantly higher than controls (0.54%).
  • Maternal thyroid function during gestation, type of AITD, and neonatal TRAb levels were significantly correlated with infant thyroid dysfunction.

Conclusions:

  • Maternal autoimmune thyroid disease during pregnancy adversely affects infant thyroid function.
  • Effective management of maternal AITD throughout pregnancy is vital for preventing negative neonatal outcomes.
Abstract

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