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Updated: Aug 3, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
Congenital heart defects: the patients who die
Alf Meberg1, Harald Lindberg, Erik Thaulow
1Department of Paediatrics, Vestfold Hospital Tønsberg, Tønsberg, Norway. alf.meberg@siv.no
Insights
Congenital heart defects (CHDs) contribute significantly to infant mortality, with most deaths occurring within the first year. The mortality rate for CHDs has remained unchanged over two decades.
Area of Science:
- Pediatrics
- Cardiology
- Public Health
Background:
- Congenital heart defects (CHDs) represent a significant public health concern.
- Understanding mortality patterns is crucial for improving outcomes in affected infants.
Purpose of the Study:
- To determine the mortality rates and primary causes of death in infants diagnosed with congenital heart defects (CHDs).
- To analyze trends in CHD-related mortality over time.
Main Methods:
- A prospective, population-based observational study was conducted.
- Data were collected on 553 infants with CHDs over a 22-year period.
Main Results:
- Congenital heart defects (CHDs) accounted for 21.5% of neonatal deaths.
- Overall mortality for infants with CHDs was 11.6%, with 79.7% of deaths occurring within the first year of life.
- Mortality rates did not significantly change between 1982-1991 and 1992-2002 cohorts.
Conclusions:
- Congenital heart defects (CHDs) are a substantial contributor to neonatal mortality.
- Cardiac insufficiency is the primary cause of death in most cases.
- The mortality rate associated with CHDs has remained consistent.
Aims:
To register mortality and causes of death in patients with congenital heart defects (CHDs).
Methods:
Prospective population-based observational study.
Results:
553 infants with CHD (1.1% of live born) were observed for 1-22 y (median 10 7/12 y). Sixty-four died (11.6%), of whom 32 (50%) died during the first 4 wk, and 51 (79.7%) during the first year of life. Of the total neonatal deaths in the population (3 per 1000), CHDs occurred in 21.5%. Mortality for children with CHDs was not significantly different between the cohorts born in 1982-1991 and 1992-2002, for either neonatal deaths or deaths later on (p>0.05). Out of 170 patients in whom therapeutic procedures (surgery, catheter interventions) were undertaken, 34 (20%) died. Nine cases (1.6%) died with unrecognized CHDs; seven of these on the first day of life with severe extracardiac malformations. In 50 (78.1%) cases, death was judged to be caused directly or indirectly from the CHD, and in 14 (21.9%) from extracardiac malformations or other conditions.
Conclusion:
CHDs occur in a substantial number of neonatal deaths. Most deaths are caused by cardiac insufficiency. The mortality rate remained unchanged.
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