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Comparative in vitro activity of ceftobiprole against staphylococci displaying normal and small-colony variant
Christof von Eiff1, Alexander W Friedrich, Karsten Becker
1Institute of Medical Microbiology, University of Münster Hospital and Clinics, Germany. eiffc@uni-muenster.de
Abstract:
The antistaphylococcal activity of ceftobiprole was compared with those of cefuroxime, linezolid, and moxifloxacin by using the agar dilution method. Apart from three strains with small-colony variant phenotypes, all Staphylococcus aureus isolates tested were inhibited by < or =2 microg/ml of ceftobiprole. This compound exhibited an excellent antistaphylococcal activity, comparable to that of linezolid.
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