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Microscopic polyangiitis after silicone breast implantation
Masayuki Iyoda1, Jyun Ito, Hisako Nagai
1Department of Nephrology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan, iyoda@med.showa-u.ac.jp
Clinical and Experimental Nephrology
|September 29, 2005
Summary
This case report details a patient who developed microscopic polyangiitis (MPA) following silicone breast implants. The findings suggest a potential link between silicone implants and MPA development.
Area of Science:
- Nephrology
- Rheumatology
- Immunology
Background:
- Silicone breast implantation is a common cosmetic procedure.
- Autoimmune diseases, including scleroderma, lupus, and rheumatoid arthritis, have been associated with silicone implants.
Observation:
- A 60-year-old woman presented with malaise and hematuria after silicone breast implantation.
- Clinical presentation included acute progressive renal failure and pulmonary hemorrhage.
Findings:
- Diagnosis of microscopic polyangiitis (MPA) was confirmed by positive myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA) and renal biopsy findings.
- Renal biopsy revealed severe necrotizing and crescentic glomerulonephritis with arteriolitis.
- Despite treatment with high-dose steroids and plasma exchange, the patient experienced fatal pulmonary and cerebral hemorrhages.
Implications:
- This case highlights a potential, previously unreported association between silicone breast implantation and the development of microscopic polyangiitis.
- Further research is warranted to investigate the potential etiological role of silicone implants in MPA pathogenesis.