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Renal artery changes in patients with primary renal cell carcinoma

K Tomić1, D Tomas, I Tomasković

  • 1General Hospital Josip Bencević, Slavonski Brod, Croatia.

Virchows Archiv : an International Journal of Pathology
|September 29, 2005
PubMed

Insights

Fibromuscular dysplasia (FMD), a renal artery condition, was found in a significant number of patients with renal cell carcinoma (RCC), particularly women. Further research is needed to understand the FMD-RCC relationship.

Area of Science:

  • Vascular pathology
  • Oncology

Background:

  • Arterial fibromuscular dysplasia (FMD) is a nonatherosclerotic, occlusive arterial disease, frequently impacting renal arteries.
  • Renal cell carcinoma (RCC) is linked to arterial hypertension, but its association with renal artery changes remains unexplored.

Purpose of the Study:

  • To investigate the prevalence of renal artery changes, specifically FMD, in patients with RCC.
  • To explore potential relationships between RCC, FMD, and systemic hypertension.

Main Methods:

  • Histopathological analysis of renal arteries from 57 patients who underwent nephrectomy for RCC.
  • Routine staining (hematoxylin and eosin, Mallory trichrome, orcein) and microscopic examination of arterial specimens.

Main Results:

  • Renal artery changes were observed in 33 patients (57.9%).
  • Fibromuscular dysplasia (FMD) was identified in 24 patients (42.1%), predominantly in women (14 female, 10 male).
  • Atherosclerotic changes were noted in 7 patients (12.3%).

Conclusions:

  • FMD is present in a significant proportion of patients with RCC, suggesting a potential association.
  • The findings highlight the need for further investigation into the underlying mechanisms connecting FMD, RCC, and hypertension.

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