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Metabolic pathway of magnetized fluid-induced relaxation effects on heart muscle

Gayane Ayrapetyan1, Alexander Papanyan, Hovik Hayrapetyan

  • 1UNESCO Chair-Life Sciences International Postgraduate Educational Center, Yerevan, Armenia.

Bioelectromagnetics
|September 29, 2005
PubMed

Insights

Magnetized physiological solution (MPS) relaxes snail heart muscle at room temperature by reducing intracellular calcium, likely via cGMP activation. This effect is absent in cold conditions, impacting cAMP and calcium uptake.

Area of Science:

  • Cardiovascular Physiology
  • Biophysics
  • Cellular Signaling

Background:

  • Cardiac muscle contractility is regulated by intracellular ion concentrations and second messengers.
  • The influence of physical factors like magnetic fields on physiological processes is an area of ongoing research.

Purpose of the Study:

  • To investigate the effects of magnetized physiological solution (MPS) on isolated snail heart muscle.
  • To determine the impact of MPS on cardiac contractility, calcium uptake, and intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP).

Main Methods:

  • Isolated, perfused snail heart muscle preparations were utilized.
  • Experiments were conducted at different temperatures (22°C and 4°C).
  • Measurements included muscle contractility, (45)Ca uptake, and intracellular cAMP and cGMP levels.

Main Results:

  • MPS demonstrated a relaxing effect on snail heart muscle at room temperature (22°C), but not in cold conditions (4°C).
  • MPS significantly decreased (45)Ca uptake and intracellular cAMP levels.
  • MPS increased intracellular cGMP levels.

Conclusions:

  • The relaxing effect of MPS on cardiac muscle is proposed to result from decreased intracellular calcium, potentially mediated by cGMP-dependent calcium efflux.
  • Reduced intracellular cAMP levels due to MPS may stem from calcium loss, leading to Na+/K+-ATPase reactivation and subsequent changes in ATP levels affecting cyclase activity.

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