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Diazepam tolerance effects on vestibular function testing, Part I: Saccadic parameters during electronystagmography.

Patricia A Blau¹, Nathan Schwade, Peter Roland

¹Dept of Otorhinolaryngology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-8876, USA.

The Annals of Otology, Rhinology, and Laryngology

|September 30, 2005

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Diazepam (DZ) affects saccadic eye movements and sedation, with tolerance impacting these measures over time. These findings question the necessity of discontinuing DZ before vestibular testing.

Area of Science:

Neuroscience
Vestibular System Research
Pharmacology

Background:

Benzodiazepines, like diazepam (DZ), are clinically used for acute vestibular symptom suppression.
Limited research exists on diazepam tolerance effects on vestibular, oculomotor, and balance system interactions.

Purpose of the Study:

To investigate the impact of diazepam tolerance on saccadic eye movements and sedation.
To assess the interaction between the vestibular, oculomotor, and balance systems under diazepam exposure.

Main Methods:

A double-blinded, repeated-measures study involving 30 healthy men.
Randomization into diazepam and placebo groups over 16 days.
Electro-oculography used to assess saccadic eye movements and sedation.

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Main Results:

Diazepam selectively affected saccadic latency and sedation (p < .05).
Significant changes in saccadic latency and accuracy, and sedation ratings were observed between baseline, day 3, and day 16 in the diazepam group.
No significant time effects were noted for other measured variables.

Conclusions:

Saccadic latency, accuracy, and sedation ratings are sensitive indicators of diazepam's effects over time.
Subject variability is less influential on these measures compared to saccadic eye velocity.
The necessity of discontinuing diazepam 48 hours prior to testing requires further investigation.