Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recurrent venous thrombosis with factor V Leiden mutation.

S Meenakshi-Sundaram1, Rohini Sridhar, J J Jithendrian

  • 1Department of Neurosciences, Apollo Speciality Hospitals, Lake View Road, KK Nagar, Madurai, Tamil Nadu.

The Journal of the Association of Physicians of India
|September 30, 2005
PubMed
Summary

Factor V Leiden mutation can cause recurrent blood clots, including deep vein thrombosis and cerebral venous thrombosis. Genetic testing is crucial for patients with unexplained or repeated clotting events.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unusual case of temporal dermoid cyst presenting as oculomotor nerve palsy.

Indian journal of ophthalmology·2014
Same author

Relapsing Guillain-Barre syndrome in pregnancy and postpartum.

Annals of Indian Academy of Neurology·2014
Same author

Complete recovery following intra-arterial tenecteplase administration in a woman with acute ischemic stroke.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2013
Same author

Eosinophilic gastroenteritis: a diagnosis behind the curtains.

Journal of clinical and diagnostic research : JCDR·2013
Same author

Giant cell tumor of tendon sheath mimicking pyogenic granuloma in the index finger pulp: a case report.

Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand·2012
Same author

Recombinant factor VIIa in a case of pontine hemorrhage.

The Journal of the Association of Physicians of India·2008

Area of Science:

  • Internal Medicine
  • Hematology
  • Genetics

Background:

  • Recurrent venous thromboembolism poses a significant clinical challenge.
  • Identifying underlying hypercoagulable states is essential for effective management.
  • Factor V Leiden mutation is a common inherited thrombophilia.

Observation:

  • A patient experienced recurrent venous thrombosis, initially deep vein thrombosis of the lower limb, followed by cerebral venous thrombosis.
  • The patient had a history of discontinuing oral anticoagulant therapy.
  • Partial improvement was noted with anticoagulant therapy for cerebral venous thrombosis.

Findings:

  • Polymerase chain reaction (PCR) analysis identified the factor V Leiden mutation.
  • This genetic mutation was confirmed as the cause of the patient's hypercoagulable state.

Related Experiment Videos

  • Long-term anticoagulation therapy has been recommended.

    • Implications:

    • Testing for factor V Leiden mutation is strongly indicated in patients with spontaneous thrombosis.
    • Early diagnosis and appropriate anticoagulation can prevent recurrent thrombotic events.
    • Genetic screening aids in personalized risk assessment and long-term treatment strategies for thrombophilia.