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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
Published on: August 14, 2017
[Changes of plasma von Willebrond factor and soluble E-selectin levels in patients with coronary artery disease]
Guo-qiang Lin1, Hai-he Jiang, Ying-qiu Li
1Department of Cardiopulmonary Surgery of Xiangya Hospital, Central South University, Changsha 410008, China. lgq186snoopy@tom.com
Insights
Elevated plasma levels of von Willebrand factor (vWF) and soluble E-selectin (sE-selectin) are associated with coronary artery disease (CAD). These markers may play a role in CAD development and severity assessment.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Biomarkers
Context:
- Coronary artery disease (CAD) is a significant global health concern.
- Understanding the molecular mechanisms and identifying reliable biomarkers for CAD is crucial for diagnosis and management.
Purpose:
- To investigate the plasma levels of von Willebrand factor (vWF) and soluble E-selectin (sE-selectin) in patients with CAD.
- To evaluate the clinical significance and potential role of these markers in the pathogenesis and severity of CAD.
Summary:
- Plasma vWF and sE-selectin levels were significantly elevated in CAD patients compared to healthy controls.
- While vWF levels did not differ significantly across CAD subtypes (AMI, UA, SA), sE-selectin levels were higher in acute myocardial infarction (AMI) and unstable angina (UA) groups compared to stable angina (SA).
- Increased vWF and sE-selectin may serve as risk factors and indicators in the development and clinical assessment of CAD.
Impact:
- Identifies vWF and sE-selectin as potential biomarkers for CAD risk and progression.
- Provides insights into the role of endothelial dysfunction and inflammation in CAD pathogenesis.
- Suggests sE-selectin as a valuable marker for evaluating the clinical severity of CAD.
Objective:
To observe the changes of plasma von Willebrand factor (vWF) and soluble E-selectin (sE-selectin) in patients with coronary artery disease (CAD) and evaluate their clinic significance.
Methods:
The level of plasma vWF and sE-selectin of 60 cases with coronary artery disease were detected by enzyme-linked immunosorbent assay (ELISA) and 20 healthy persons acted as the control group. Risk factors for coronary artery disease were obtained by asking the medical history and the relation ship was analyzed with coronary artery disease.
Results:
The plasma vWF and sE-selectin levels of CAD patients were significantly higher than those of the control group (P = 0.017 and P < 0.001). There was no significant difference in plasma vWF levels between the acute myocardial infarction (AMI) group and the unstable angina pectoris (UA) group or the SA group (P = 0.210 and P = 0.194). The plasma vWF level of the SA group were higher than that of the UA group (P = 0.012). The plasma levels of sE-selectin of AMI group, and the UA group were higher than those of the SA group (P < 0.001 and P = 0.010). There were no significant differences between the SA group and the control group (P = 0.284) and between the AMI group and the UA group (P = 0.066).
Conclusion:
The increased plasma vWF or sE-selectin level may be risk factors for CAD and they may be involved in the pathogenesis of CAD. The increase of plasma sE-selectin is correlated to the generation and development of CAD and it is important in the evaluation of clinical severity of CAD.
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