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Updated: Aug 9, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
Published on: January 27, 2014
Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2
Richard E Armer1, Mark R Ashton, Edward A Boyd
1Oxagen Ltd., 91 Milton Park, Abingdon, Oxfordshire, OX14 4RY, UK. r.armer@oxagen.co.uk
Abstract:
Prostaglandin D2 (PGD2) acting at the CRTH2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells) has been linked with a variety of allergic and other inflammatory diseases. We describe a family of indole-1-sulfonyl-3-acetic acids that are potent and selective CRTH2 antagonists that possess good oral bioavailability. The compounds may serve as novel starting points for the development of treatments of inflammatory disease such as asthma, allergic rhinitis, and atopic dermatitis.
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