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General measures of cognition.
1Silberstein Institute for Aging and Dementia, New York University School of Medicine, New York 10016, USA. steven.ferris@med.nyu.edu
International Psychogeriatrics
|September 30, 2005
Summary
A new cognitive tool, the Vascular Dementia Assessment Scale-Cognitive (VaDAS-cog), has been developed for clinical trials. It enhances the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-cog) to better measure vascular dementia.
Area of Science:
- Neurology
- Neuropsychology
- Clinical Trials
Background:
- Vascular dementia (VaD) and Alzheimer's disease (AD) share cognitive impairment patterns.
- A sensitive cognitive performance battery is crucial for VaD clinical trials.
Purpose of the Study:
- To develop an optimized cognitive assessment tool for vascular dementia.
- To enhance an existing Alzheimer's disease measure for VaD.
Main Methods:
- Modified the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-cog).
- Incorporated additional subtests targeting frontal lobe functions.
- Included assessments for attention, working memory, executive function, and verbal fluency.
Main Results:
- The Vascular Dementia Assessment Scale-Cognitive (VaDAS-cog) was developed.
- The VaDAS-cog includes enhanced measures for cognitive domains prominent in VaD.
Conclusions:
- The VaDAS-cog is a promising cognitive instrument for VaD research.
- Successful use in clinical trials will validate the VaDAS-cog's efficacy.