Related Experiment Video
Updated: Aug 15, 2026

Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
[The transformation of fibroblast-like cells originating from different tissue into osteoblasts]
Quan-feng Luo1, Xing Wang, Biao Yi
1Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology, Beijing 100081, China.
Objective:
To discuss whether fibroblast-like cells can transform into osteoblasts under specific condition during distraction osteogenesis.
Methods:
Fibroblast-like cells were cultured in vitro. BMP-2, TGF-beta(1), BMP-2 and TGF-beta(1) were added into the medium, and the cellular change were observed by histochemistry and immunohistochemistry methods. The distraction was given on the membrane of fibroblast-like cells, and the cellular change were observed under the distraction.
Results:
fibroblast-like cells from the joint could transform into osteoblasts under the effect of BMP-2 or BMP-2 with TGF-beta(1). Fibroblast-like cells from other regions could not transform into osteoblasts.
Conclusion:
The osteoblasts during distraction osteogenesis are multi-origin.
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