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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...

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Updated: Jul 10, 2026

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
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Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Published on: May 2, 2011

SARS vaccine: progress and challenge.

Yan Zhi1, James M Wilson, Hao Shen

  • 1Gene Therapy Program, Division of Medical Genetics, Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.

Cellular & Molecular Immunology
|September 30, 2005
PubMed
Summary
This summary is machine-generated.

Severe acute respiratory syndrome (SARS) is a contagious disease caused by SARS-CoV. Continued research is vital for developing a SARS vaccine to prevent future outbreaks.

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Area of Science:

  • Virology
  • Immunology
  • Epidemiology

Background:

  • Severe acute respiratory syndrome (SARS) emerged in 2002 as a highly contagious infectious disease.
  • The SARS outbreak spread globally, necessitating rapid scientific investigation.
  • Concerns persist about potential SARS-CoV resurgence from animal reservoirs or laboratory incidents.

Purpose of the Study:

  • To summarize current understanding of SARS-CoV molecular biology and immunology.
  • To emphasize the need for a SARS vaccine to prevent future epidemics.

Main Methods:

  • Collaborative global scientific research efforts.
  • Analysis of molecular biology and immunology data.

Main Results:

  • Substantial insights into SARS-CoV molecular biology and immunology were gained.
  • The SARS outbreak was successfully contained.

Conclusions:

  • Despite containment, the threat of SARS reemergence remains.
  • Development of an effective SARS vaccine is crucial for future public health security.