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Calcinosis cutis with siliconomas complicated by hypercalcemia
Seng Cheong Loke1, Melvin Khee-Shing Leow
1Department of Endocrinology, Tan Tock Seng Hospital, Singapore.
Summary
Extensive calcinosis cutis, a condition of calcium deposits in the skin, can lead to severe hypercalcemia. This case highlights the potential complications of silicone injections and granulomatous reactions.
Area of Science:
- Dermatology
- Endocrinology
- Pathology
Background:
- Calcinosis cutis is characterized by calcium salt deposition in the skin.
- Silicone injections are increasingly used for cosmetic and reconstructive purposes.
- Hypercalcemia, elevated calcium levels in the blood, can have serious systemic consequences.
Observation:
- A 78-year-old woman presented with severe hypercalcemia.
- Extensive subcutaneous calcifications were noted on the anterior chest wall and abdomen.
- These calcifications were presumed to be related to prior silicone injections.
Findings:
- The patient's hypercalcemia was successfully treated with pamidronate and rehydration.
- Surgical resection of the calcific deposits was not feasible.
- The underlying cause of hypercalcemia was potentially a granulomatous reaction and vitamin D excess.
Implications:
- Extensive calcinosis cutis poses a risk for developing hypercalcemia.
- This case underscores the importance of considering iatrogenic causes for calcinosis cutis.
- Understanding the mechanisms of hypercalcemia in calcinosis cutis is crucial for patient management.