Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Meiotic abnormalities in infertile males.

J Egozcue1, Z Sarrate, M Codina-Pascual

  • 1Departament de Biologia Cellular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain. josep.egozcue@uab.es

Cytogenetic and Genome Research
|September 30, 2005
PubMed
Summary

Synaptic anomalies, or germ cell chromosome errors, are linked to male infertility and can lead to chromosomally abnormal embryos. Early detection through meiotic studies is crucial for understanding reproductive outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Growth and properties of hybrid Au-Co<sub>0.8</sub>Ni<sub>0.2</sub>nanowires embedded in SrTiO<sub>3</sub>/SrTiO<sub>3</sub>(001).

Nanotechnology·2024
Same author

Management of women with abnormal uterine bleeding: Clinical practice guidelines of the French National College of Gynaecologists and Obstetricians (CNGOF).

European journal of obstetrics, gynecology, and reproductive biology·2023
Same author

Time to match; when do homologous chromosomes become closer?

Chromosoma·2022
Same author

Quality of life of patients with bilateral oophorectomy before the age of 45 for the treatment of endometriosis.

Maturitas·2022
Same author

[Management of women with abnormal uterine bleeding: Clinical practice guidelines of the French National College of Gynecologists and Obstetricians (CNGOF)].

Gynecologie, obstetrique, fertilite & senologie·2022
Same author

Robot-assisted laparoscopy for deep infiltrating endometriosis: a retrospective French multicentric study (2008-2019) using the Society of European Robotic Gynecological Surgery endometriosis database.

Archives of gynecology and obstetrics·2022

Area of Science:

  • Reproductive Biology
  • Human Genetics
  • Cytogenetics

Background:

  • Synaptic anomalies are chromosome abnormalities specific to germ cells, often undetected by standard karyotyping.
  • These errors in synapsis are increasingly recognized as a significant factor in male infertility.
  • The clinical impact of synaptic anomalies on reproductive success has been historically underestimated.

Purpose of the Study:

  • To review the nature and clinical significance of synaptic anomalies in human male infertility.
  • To discuss diagnostic approaches for identifying meiotic errors in germ cells.
  • To highlight the consequences of synaptic anomalies for sperm and embryo quality.

Main Methods:

  • Immunostaining of synaptonemal complexes (SCs) for studying synaptic anomalies.

Related Experiment Videos

  • Analysis of classic meiotic preparations, enhanced by multiplex fluorescence in situ hybridization (FISH).
  • Sperm chromosome FISH studies as an indirect diagnostic method.

    • Main Results:

    • Synaptic anomalies can manifest as altered recombination rates, univalents, or achiasmate bivalents.
    • Incidence ranges from a baseline of 6-8% to higher rates (17.6%-27%) in infertile males or those with IVF failures.
    • These anomalies lead to the production of abnormal spermatozoa and chromosomally abnormal embryos.

    Conclusions:

    • Synaptic anomalies are a critical, though often overlooked, cause of male infertility.
    • Accurate diagnosis requires specialized meiotic studies, particularly in cases of unexplained infertility or recurrent IVF failure.
    • Understanding synaptic anomalies is essential for improving male reproductive health and assisted reproductive technologies outcomes.