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Published on: January 19, 2019
Control of cancers by combining antiangiogenesis and cancer immunotherapy
Michelle Moniz1, Jessica Yeatermeyer, T-C Wu
1Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA.
Abstract:
Ideally, cancer therapy would eliminate tumor growth at multiple sites in the body without damaging normal cells. In this regard, antiangiogenesis and immunotherapy may represent two potential approaches for control of cancers. Inhibition of tumor-specific angiogenesis restrains neoplastic growth by sequestering cancerous cells from an adequate blood supply, while activation of cancer-specific T cell-mediated immune responses can initiate attacks on tumors associated with a specific antigen. A novel approach that combines both strategies may potentially generate a better antitumor effect. In this review, we will outline the fields of cancer antiangiogenesis and cancer immunotherapy, including their advantages and limitations. In addition, we will discuss the feasibility of combining both mechanisms to generate a more powerful strategy for cancer therapy.
Insights
Combining antiangiogenesis and immunotherapy offers a promising dual approach to cancer treatment. This strategy aims to cut off tumor blood supply and activate immune responses for enhanced antitumor effects.
Area of Science:
- Oncology
- Immunology
- Vascular Biology
Background:
- Current cancer therapies aim for targeted tumor elimination without harming healthy tissues.
- Antiangiogenesis inhibits tumor growth by restricting blood supply.
- Immunotherapy activates T cells to attack tumors expressing specific antigens.
Purpose of the Study:
- To review the fields of cancer antiangiogenesis and immunotherapy.
- To discuss the advantages and limitations of each approach.
- To explore the potential of combining antiangiogenesis and immunotherapy for improved cancer treatment.
Main Methods:
- Literature review of antiangiogenesis strategies.
- Literature review of cancer immunotherapy approaches.
- Discussion of the synergistic potential of combined therapies.
Main Results:
- Antiangiogenesis limits tumor expansion by controlling neovascularization.
- Immunotherapy leverages the host immune system for tumor surveillance and destruction.
- Combining these strategies may offer a more potent and comprehensive antitumor effect.
Conclusions:
- A combined antiangiogenesis and immunotherapy approach presents a novel and potentially superior strategy for cancer therapy.
- Further research is warranted to elucidate the optimal combination protocols and clinical applications.
- This integrated approach holds promise for overcoming limitations of single-modality treatments.
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