Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antibody Structure01:10

Antibody Structure

65.5K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.5K
Antibody Actions01:26

Antibody Actions

2.7K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
2.7K
Antibody Structure and Classes01:25

Antibody Structure and Classes

9.1K
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
9.1K
Adult Stem Cells01:33

Adult Stem Cells

33.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.9K
Affinity and Avidity01:41

Affinity and Avidity

39.0K
Overview
39.0K
Humoral Immune Responses01:36

Humoral Immune Responses

83.9K
Overview
83.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-Pim-1 mAb inhibits activation and proliferation of T lymphocytes and prolongs mouse skin allograft survival.

Cellular immunology·2011
Same author

Pim-1 expression and monoclonal antibody targeting in human leukemia cell lines.

Experimental hematology·2009
Same author

PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.

The Journal of clinical investigation·2009
Same author

MUC1 cytoplasmic tail: a potential therapeutic target for ovarian carcinoma.

Expert review of anticancer therapy·2006
Same author

The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene.

Journal of immunology (Baltimore, Md. : 1950)·2006
Same author

MDX-060. Medarex.

Current opinion in investigational drugs (London, England : 2000)·2005
Same journal

New drug discovery and development in India.

Drug news & perspectives·2013
Same journal

Are we living in the end of the blockbuster drug era?

Drug news & perspectives·2010
Same journal

Molecule of the Month. TAK-875.

Drug news & perspectives·2010
Same journal

Epigenetic alterations of tumor marker microRNAs: towards new cancer therapies.

Drug news & perspectives·2010
Same journal

Electroporation: a promising method for the nonviral delivery of DNA vaccines in humans?

Drug news & perspectives·2010
Same journal

Trioxaquines: hybrid molecules for the treatment of malaria.

Drug news & perspectives·2010
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Generation of Monoclonal Antibodies Against Natural Products
12:15

Generation of Monoclonal Antibodies Against Natural Products

Published on: April 6, 2019

11.6K

Cripto monoclonal antibodies.

Xiu Feng Hu1, Pei Xiang Xing

  • 1Cancer Immunotherapy Laboratory, Austin Research Institute, Victoria, Australia.

Drug News & Perspectives
|September 30, 2005
PubMed
Summary
This summary is machine-generated.

Targeting the Cripto protein, particularly its EGF-like and CFC regions, with monoclonal antibodies (MAbs) shows promise for cancer immunotherapy by inhibiting tumor growth and metastasis.

More Related Videos

Generation of Murine Monoclonal Antibodies by Hybridoma Technology
09:42

Generation of Murine Monoclonal Antibodies by Hybridoma Technology

Published on: January 2, 2017

43.7K
Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
09:57

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

12.4K

Related Experiment Videos

Last Updated: Feb 1, 2026

Generation of Monoclonal Antibodies Against Natural Products
12:15

Generation of Monoclonal Antibodies Against Natural Products

Published on: April 6, 2019

11.6K
Generation of Murine Monoclonal Antibodies by Hybridoma Technology
09:42

Generation of Murine Monoclonal Antibodies by Hybridoma Technology

Published on: January 2, 2017

43.7K
Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
09:57

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

12.4K

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunotherapy

Background:

  • Cripto, a member of the EGF-CFC family, is crucial in embryonic development and is upregulated in most epithelial cancers.
  • Cripto expression correlates with tumorigenesis, invasion, and metastasis, mimicking epithelial-mesenchymal transition (EMT).

Purpose of the Study:

  • To review the role of Cripto in cancer and highlight its potential as a therapeutic target for monoclonal antibody (MAb) intervention.
  • To emphasize the significance of the EGF-like and CFC regions of Cripto for targeted cancer therapy.

Main Methods:

  • Review of existing literature on Cripto's function in cancer.
  • Analysis of Cripto's role in tumor growth, EMT, and metastasis.
  • Discussion of MAb-based therapeutic strategies targeting Cripto.

Main Results:

  • The EGF-like region of Cripto is critical for Cripto signaling-mediated tumor growth and EMT, suggesting it as a target for MAb intervention, likely via c-Src signaling.
  • The CFC region of Cripto binds activin B, stimulating cell proliferation; MAbs targeting this region inhibit Cripto-activin B binding and reduce cell growth.

Conclusions:

  • Monoclonal antibodies targeting Cripto, specifically its EGF-like and CFC regions, represent a potential therapeutic strategy for various cancers.
  • Targeting Cripto offers a novel approach to cancer immunotherapy by disrupting key signaling pathways involved in tumor progression and metastasis.