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Updated: Jul 31, 2026

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1
Published on: March 18, 2017
Recognition of guanines at a double helix-coil junction in DNA by a trinuclear copper complex
Takeo Ito1, Sunita Thyagarajan, Kenneth D Karlin
1Department of Chemistry and Biochemistry, University of Maryland, College Park, 20742, USA.
Abstract:
Coordination between guanine N7 and a trinuclear copper complex appears critical for selective and efficient strand scission of DNA at a helix-coil junction as indicated by the lack of reactivity of comparable DNA containing 7-deazaguanine in place of guanine; both the base pair at the junction and coil flexibility also modulate the specificity of DNA oxidation.
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