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Updated: Aug 15, 2026

Investigating Interactions Between Histone Modifying Enzymes and Transcription Factors in vivo by Fluorescence Resonance Energy Transfer
Published on: October 14, 2022
A family of putative transcription termination factors shared amongst metazoans and plants
Tomas Linder1, Chan Bae Park, Jordi Asin-Cayuela
1Department of Laboratory Medicine, Division for Metabolic Diseases, Karolinska Institutet, Novum, SE-14186, Huddinge, Sweden.
Abstract:
The human mitochondrial transcription termination factor (mTERF) is involved in the regulation of transcription of the mitochondrial genome. Similarity searches and phylogenetic analysis demonstrate that mTERF is a member of large and complex protein family (the MTERF family) shared amongst metazoans and plants. Interestingly, we identify three novel MTERF genes in vertebrates, which all encode proteins with predicted mitochondrial localization. Members of the MTERF family have so far not been detected in fungi, supporting the notion that mitochondrial transcription regulation may have evolved separately in yeast and animal cells.
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