Related Experiment Video

Updated: Jul 28, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

[Preseptal and orbital cellulitis in childhood: response to intravenous antibiotics]

M C Durán-Giménez-Rico1, A Boto-de-los-Bueis, M J Alberto

  • 1Hospital San Rafael, Madrid, Spain.

Archivos De La Sociedad Espanola De Oftalmologia
|September 30, 2005
PubMed

Insights

Empiric antibiotic treatment for pediatric preseptal and orbital cellulitis showed varied responses. Cefotaxime was more effective than cefuroxime, especially when acute dacryocystitis was present.

Area of Science:

  • Ophthalmology
  • Pediatric Infectious Diseases

Background:

  • Preseptal and orbital cellulitis are common pediatric infections.
  • Empiric antibiotic therapy is the standard initial treatment.

Purpose of the Study:

  • To retrospectively evaluate the effectiveness of empiric antibiotic treatment for preseptal and orbital cellulitis in children.
  • To compare the response rates of different antibiotics and identify potential contributing factors.

Main Methods:

  • Retrospective review of nine pediatric patients diagnosed with preseptal or orbital cellulitis between October 2002 and October 2003.
  • Analysis of patient demographics, clinical presentation, associated conditions, and antibiotic treatment regimens.

Main Results:

  • 44.4% of patients responded to initial empiric antibiotic treatment; 55.5% required a second antibiotic.
  • Cefotaxime was effective in 3 out of 4 patients, while cefuroxime was effective in only 1 out of 5 patients.
  • Acute dacryocystitis was identified in two non-responding patients and was associated with a lack of response to cefuroxime.

Conclusions:

  • Acute dacryocystitis is a significant underlying cause of pediatric preseptal and orbital cellulitis.
  • Cefotaxime demonstrated a better response rate compared to cefuroxime for empiric treatment.
  • Prompt identification and management of acute dacryocystitis are crucial for successful treatment outcomes.
Abstract

More Related Videos

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Intracameral Injection in Rats with Low Risk of Adverse Effects06:19

Intracameral Injection in Rats with Low Risk of Adverse Effects

Published on: May 31, 2024

Related Concept Videos

Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...