Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuromyelitis optica with hypothalamic involvement.

Alexandre Y Poppe1, Yves Lapierre, Denis Melançon

  • 1McGill University Health Centre, The Montreal Neurological Institute and Hospital, 3801 University Street, Montreal, Quebec, Canada.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|October 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex differences in brain frailty measures and outcomes after endovascular thrombectomy: ESCAPE-NA1 analysis.

Journal of the neurological sciences·2026
Same author

Automated perfusion imaging did not improve reliability of ASPECTS or collateral score in late-window large vessel occlusion stroke.

Journal of neurointerventional surgery·2026
Same author

Endovascular Acute Stroke Intervention-Tandem Occlusion (EASI-TOC) study: protocol and rationale.

European stroke journal·2026
Same author

Poor Cortical Venous Opacification on Baseline Computed Tomography Angiography Predicts Parenchymal Hemorrhage After Thrombectomy.

Stroke (Hoboken, N.J.)·2026
Same author

Nerinetide Reduces Early Infarct Growth Among Stroke Patients Undergoing EVT Without Intravenous Alteplase.

Stroke (Hoboken, N.J.)·2026
Same author

Ability of Radiomics Versus Humans in Predicting First-Pass Effect After Endovascular Treatment in the ESCAPE-NA1 Trial.

Stroke (Hoboken, N.J.)·2026
Same journal

Association of epiretinal membranes with disability in people with multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Epiretinal membranes in multiple sclerosis: A window into glial pathobiology?

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Profiling the long-term risk of severe adverse events in a cohort of multiple sclerosis patients treated with different treatment sequences: Results from the Italian Multiple Sclerosis and Related Disorders Registry (I-MS&RD) (ProSA study).

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

UK consensus on pregnancy in multiple sclerosis: An update to 'Association of British Neurologists' guidance.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Comparative effectiveness of rituximab versus ocrelizumab in relapsing multiple sclerosis on clinical relapses and radiological outcomes in British Columbia, Canada.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Invisible symptoms in multiple sclerosis and their impact on social role participation: A multidimensional analysis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
See all related articles

This study reports two neuromyelitis optica (NMO) cases with hypothalamic lesions. Findings suggest current NMO diagnostic criteria may need updating to include hypothalamic involvement.

Area of Science:

  • Neuroimmunology
  • Neurology

Background:

  • Neuromyelitis optica (NMO) is an autoimmune disorder affecting the central nervous system.
  • Current diagnostic criteria for NMO primarily focus on optic nerve and spinal cord lesions.

Observation:

  • Two patients with NMO presented with clinical and radiographic evidence of hypothalamic lesions.
  • These patients had no other brain parenchymal lesions, and their disease course was typical of Devic's disease.
  • A literature review revealed additional NMO cases with symptoms suggestive of hypothalamic-pituitary axis dysfunction.

Findings:

  • The hypothalamus can be a primary site of involvement in neuromyelitis optica.
  • Clinical manifestations of hypothalamic dysfunction in NMO are often under-recognized.

Related Experiment Videos

Implications:

  • Revisiting and potentially expanding NMO diagnostic criteria to include hypothalamic lesions is proposed.
  • This may improve the early diagnosis and management of NMO patients with hypothalamic involvement.