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Updated: Aug 15, 2026
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
[The effect of neoadjuvant chemotherapy on estrogen and progesterone receptor expression in breast carcinoma]
Shu Wang1, Jia-qing Zhang, Xin-min Qiao
1Department of Breast, People's Hospital, Peking University, Beijing 100044, China. dr.wangshu@263.net
Objective:
To investigate the effect of neoadjuvant chemotherapy on estrogen receptor (ER) and progesterone receptor (PR) expression in breast carcinoma.
Methods:
Samples were obtained from 31 patients with breast carcinoma who received neo-adjuvant chemotherapy, ER or PR expressions were analyzed in preoperative core biopsies and final surgical specimens.
Results:
ER level was up-regulated in 13 (41.9%) out of 31 cases, PR level was up-regulated in 10 (32.3%). Both ER level and PR level were up-regulated in 8 (25.8%) out of 31 cases.
Conclusions:
Neoadjuvant chemotherapy may impact the hormone receptor status, ER and PR expression re-analysis in final surgical specimens is recommended.