Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Contrasting hippocampal and perirhinal cortex function using immediate early gene imaging.

John P Aggleton1, Malcolm W Brown

  • 1School of Psychology, Cardiff University, Wales, UK. aggleton@cf.ac.uk

The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology
|October 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diencephalic integrity explains aspects of hippocampal amnesia.

Cerebral cortex (New York, N.Y. : 1991)·2026
Same author

Mind the gap - Interthalamic adhesions in prodromal and clinical Alzheimer's disease.

Brain research bulletin·2025
Same author

Functional and Regional Specificity of Noradrenergic Signaling for Encoding and Retrieval of Associative Recognition Memory in the Rat.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction.

Nature medicine·2024
Same author

Disrupting direct inputs from the dorsal subiculum to the granular retrosplenial cortex impairs flexible spatial memory in the rat.

The European journal of neuroscience·2024
Same author

Scene-selectivity in CA1/subicular complex: Multivoxel pattern analysis at 7T.

Neuropsychologia·2023

The perirhinal cortex and hippocampus play distinct roles in memory. Hippocampal activity increases with spatial learning, while the perirhinal cortex activates with novel object recognition.

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Memory Research

Background:

  • The perirhinal cortex and hippocampus are anatomically linked, suggesting interconnected memory functions.
  • Lesion studies have yielded conflicting results regarding their distinct roles in object recognition and spatial memory.

Purpose of the Study:

  • To investigate the distinct roles of the perirhinal cortex and hippocampus in memory using immediate early gene expression.
  • To compare the utility of gene imaging (c-fos expression) with lesion studies in memory research.

Main Methods:

  • Utilized a rat model to compare neuronal activity in the perirhinal cortex and hippocampus.
  • Measured the expression of the immediate early gene c-fos as a marker of neural activity during memory tasks.
  • Assessed c-fos expression following spatial learning, novel object recognition, and novel scene tasks.

Related Experiment Videos

Main Results:

  • Hippocampal subfields showed increased c-fos activity during spatial learning tasks, while the perirhinal cortex did not.
  • The perirhinal cortex exhibited increased c-fos activity when rats encountered novel visual objects, unlike the hippocampus.
  • Rearranging familiar objects to create novel scenes specifically increased c-fos activity in the hippocampus, not the perirhinal cortex.

Conclusions:

  • Gene expression data reveal a double dissociation between the perirhinal cortex and hippocampus, supporting distinct memory functions.
  • The hippocampus is crucial for spatial memory and processing novel spatial configurations.
  • The perirhinal cortex is vital for object recognition and processing novel visual information.