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Updated: Aug 15, 2026
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Blood Collection Through Subclavian Vein Puncture in Mice
Published on: May 4, 2019
A rapid, simple, and humane method for submandibular bleeding of mice using a lancet
William T Golde1, Peter Gollobin, Luis L Rodriguez
1Plum Island Animal Disease Center/ARS, US Department of Agriculture, Greenport, NY 11944, USA. wgolde@piadc.ars.usda.gov
Lab Animal
|October 1, 2005
Summary
Researchers developed an inexpensive, single-use lancet for submandibular bleeding in mice. This tool enables quick collection of 0.2-0.5 ml blood samples without anesthesia, improving animal welfare.
Area of Science:
- Veterinary Medicine
- Animal Research
- Laboratory Animal Science
Background:
- Traditional methods for collecting mouse blood samples are often difficult or inhumane.
- Existing techniques may require anesthesia, adding complexity and potential confounding factors.
Purpose of the Study:
- To introduce a novel, cost-effective, and disposable lancet for submandibular bleeding in mice.
- To provide a method for rapid blood collection without the need for anesthesia.
Main Methods:
- Development and utilization of a disposable, single-use lancet.
- Application of the lancet to the submandibular vein of mice for blood collection.
Main Results:
- The lancet facilitates quick blood sample acquisition.
- Volumes of 0.2-0.5 ml of blood can be obtained per sample.
- The procedure does not require anesthesia for the animals.
Conclusions:
- The described lancet offers an improved method for submandibular blood collection in mice.
- This technique enhances efficiency and animal welfare in research settings.
