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A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
Published on: December 16, 2022
Prenatal sonographic features of isolated hypoplastic left heart syndrome
Theera Tongsong1, Rekwan Sittiwangkul, Surapan Khunamornpong
1Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Insights
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect. Prenatal ultrasound can identify key features like a small left ventricle and aorta, aiding early diagnosis.
Area of Science:
- Cardiology
- Prenatal Diagnosis
- Medical Imaging
Background:
- Hypoplastic left heart syndrome (HLHS) encompasses fetal conditions characterized by underdeveloped left ventricle and outflow tract.
- Early and accurate diagnosis is crucial for managing HLHS outcomes.
Observation:
- This series focused on sonographic prenatal features of isolated HLHS in 5 cases.
- Key findings include a small left ventricle, abnormal mitral valve function, and a hypoplastic ascending aorta.
Findings:
- Retrograde flow in the transverse aortic arch indicates insufficient systemic output.
- Tricuspid regurgitation is frequent, correlating with hydrops development.
- Other indicators include left ventricular hyperechoic endocardium and increased nuchal translucency.
Implications:
- Fetal echocardiography, particularly the 4-chamber view, is effective for detecting HLHS.
- Identifying these sonographic markers enables timely intervention and improved patient management.
Abstract:
Hypoplastic left heart syndrome (HLHS) is a spectrum of fetal conditions associated with severe hypoplasia of the left ventricle and left ventricular outflow tract. The purpose of this series was to focus on the sonographic prenatal features of isolated HLHS. Based on the 5 cases presented here, the prenatal sonographic features of HLHS include small-sized left ventricle, atretic or hypoplastic mitral valves with restricted motion and a small amount of antegrade flow or regurgitation, and hypoplastic ascending aorta. Retrograde flow in the transverse aortic arch strongly suggests inadequate systemic output from the left heart. Tricuspid regurgitation is common and increases the chance for the development of hydrops. Other findings may be helpful, including left ventricular hyperechoic endocardium and increased nuchal translucency at 11-14 weeks. With careful fetal echocardiography, HLHS may be readily observed on a 4-chamber view as either a small or even absent left ventricle.
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