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Oncogenes as novel targets for cancer therapy (part III): transcription factors
Zhuo Zhang1, Mao Li, Elizabeth R Rayburn
1Department of Pharmacology and Toxicology and Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA.
Abstract:
This is the third paper in a four-part serial review on potential therapeutic targeting of oncogenes. The previous parts described the involvement of oncogenes in different aspects of cancer growth and development, and considered the new technologies responsible for the advancement of oncogene identification, target validation, and drug design. Because of such advances, new specific and more efficient therapeutic agents can be developed for cancer. This part of the review continues the exploration of various oncogenes that we have grouped within seven categories: growth factors, tyrosine kinases, intermediate signaling molecules, transcription factors, cell cycle regulators, DNA damage repair genes, and genes involved in apoptosis. Part one discussed growth factors and tyrosine kinases and part two discussed intermediate signaling molecules. This portion of the review covers transcription factors and the various strategies being used to inhibit their expression or decrease their activities.
Insights
This review explores targeting oncogenes, focusing on transcription factors. Strategies to inhibit their expression or activity are discussed for developing novel cancer therapies.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Oncogenes play a crucial role in cancer development and progression.
- Advances in technology have enabled better identification and validation of oncogene targets.
- Previous parts of this review covered growth factors, tyrosine kinases, and intermediate signaling molecules.
Purpose of the Study:
- To review oncogenes, specifically focusing on transcription factors.
- To explore current strategies for inhibiting transcription factor activity or expression.
- To contribute to the development of targeted cancer therapies.
Main Methods:
- Literature review of oncogenes and therapeutic targeting strategies.
- Categorization of oncogenes into functional groups.
- Analysis of methods to inhibit transcription factor function.
Main Results:
- Transcription factors represent a key category of oncogenes.
- Various strategies exist to target transcription factors for therapeutic benefit.
- Inhibiting transcription factor expression or activity is a promising avenue for cancer treatment.
Conclusions:
- Targeting transcription factors is essential for developing effective cancer therapies.
- Continued research into novel inhibition strategies will advance oncogene-targeted drug design.
- This review provides a foundation for understanding transcription factor-based cancer treatments.
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