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Updated: Aug 15, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
Intravascular B-cell lymphoma diagnosed by skin biopsy
Katie Le1, Adrian Lim, Peter Bullpitt
1Department of Dermatology, Prince of Wales Hospital, Sydney, New South Wales, Australia. lek@sesahs.nsw.gov.au
Abstract:
A 58-year-old man presented with unexplained fever, constitutional symptoms, worsening respiratory failure and gross, generalized oedema. He was eventually diagnosed with intravascular B- cell lymphoma on a random skin biopsy. Examination of the skin showed patchy erythema and induration, with peau d'orange. Despite multiorgan failure requiring intensive care, he responded dramatically to multiagent chemotherapy (six cycles of cyclophosphamide, doxorubicin, vincristine and prednisone) and is currently in clinical remission.

