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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
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Nasal carriage of Staphylococcus aureus in house dust mite allergic patients and healthy controls

H Riechelmann1, A Essig, T Deutschle

  • 1Department of Otorhinolaryngology, University of Ulm, Ulm, Germany.

Allergy
|October 4, 2005
PubMed
Abstract

Insights

Staphylococcus aureus (SA) nasal carriage is common in allergic rhinitis patients. SA actively influences allergic rhinitis by increasing local IgE production, suggesting it

Area of Science:

  • Allergy and Immunology
  • Microbiology
  • Respiratory Medicine

Background:

  • Staphylococcal colonization can impact allergic disease severity.
  • Investigated Staphylococcus aureus (SA) nasal carriage in persistent allergic rhinitis.

Purpose of the Study:

  • To determine the frequency of SA nasal carriage in allergic rhinitis patients.
  • To explore the association between SA carriage and disease severity markers.

Main Methods:

  • Nasal lavages analyzed for SA colony-forming units in 22 allergic rhinitis patients and 18 controls.
  • Assessed nasal symptom scores, inflammatory markers (ECP, elastase), total IgE, and cytokines (IL-13/IFN-gamma ratio).

Main Results:

  • SA nasal carriage was significantly higher in allergic rhinitis patients (15/22) compared to controls (4/18).
  • Allergic SA carriers showed higher nasal symptom scores, elevated ECP, elastase, and total IgE levels.
  • A higher nasal IL-13/IFN-gamma ratio in SA carriers correlated with increased nasal total IgE.

Conclusions:

  • Nasal SA carriage is prevalent in persistent allergic rhinitis.
  • SA appears to actively modulate allergic rhinitis by enhancing local IgE production.

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