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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
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An adverse interaction between warfarin and fluoropyrimidines revisited

M Wasif Saif1

  • 1Division of Hematology/Oncology and Department of Clinical Pharmacology/Toxicology, Comprehensive Cancer Center, University of Alabama at Birmingham 35294-3300, USA. wasif.saif@ccc.uab.edu

Clinical Colorectal Cancer
|October 4, 2005
PubMed
Summary

Patients taking capecitabine or 5-fluorouracil with warfarin may experience dangerous bleeding due to altered coagulation. Frequent monitoring of anticoagulant response is crucial for dose adjustment.

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