Related Experiment Video
Updated: Aug 15, 2026

Use of an Influenza Antigen Microarray to Measure the Breadth of Serum Antibodies Across Virus Subtypes
Published on: July 26, 2019
Rat strains differ in antibody response to natural Haemophilus species infection
R Boot1, L van den Berg, H A Van Lith
1Section of Laboratory Animal Microbiology, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, Bilthoven, The Netherlands. R.Boot@rivm.nl
Abstract:
Antibody response to Haemophilus species in rat strains was monitored by enzyme-linked immunosorbent assay (ELISA) using antigens of two Haemophilus strains and a Pasteurella pneumotropica strain. Five rat strains from a breeding colony naturally infected by Haemophilus were significantly different in ELISA antibody activity and in the number of seropositive animals. BN and RP rats were (relatively) high and low responders, respectively and BUF, LEW and WAG rats were intermediate. In a second study, five rat strains were exposed to Haemophilus-infected rats, and, after six weeks, were also significantly different in ELISA antibody activity and in numbers of seropositive animals. Here, BN and LEW rats were (relatively) high and low responders, respectively, and BD IX, F344 and WKY rats were intermediate.
Related Concept Videos
Cross-reactivity
Viral Recombination
Streptococcal Pharyngitis
Diphtheria

