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Use of immunoassays in neurological diagnosis and research
1University of Illinois at Chicago Department of Neurology and Rehabilitation Medicine, 912 S. Wood Street, 855 N, M/C 796 Chicago, IL 60612, USA. mmerig@uic.edu
Objectives:
To review the use of immunoassays in the diagnosis and research of disorders affecting the nervous system.
Methods:
Systematic review of the English literature.
Results:
Immunoassays have demonstrated utility for: (1) the detection of antigen (molecules, genes, gene products, peptides, hormones and drug metabolites) and (2) the detection of an immune response (antigen-antibody complexes and specific and non-specific populations of antibodies) in serum, cerebrospinal fluid, and central nervous system tissue.
Discussion:
The specificity of the antibody-antigen interaction makes immunoassays an ideal diagnostic and research tool for the investigation of neurological disease. A number of immunoassays are available for this purpose, and the choice of a particular methodology generally depends upon whether one is detecting antigen, antibody or antigen-antibody complexes, and the nature of the biologic sample that is being tested. Ease of testing, sensitivity, specificity and cost are other important considerations.
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