Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Osteopontin, a multi-faceted molecule].

Dorothée Chabas1

  • 1Inserm U.546, Faculté de médecine Pitié-Salpêtrière, Paris, France. dchabas@chups.jussieu.fr

Medecine Sciences : M/S
|October 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19.

Medical hypotheses·2020
Same author

Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study.

BMC neurology·2013
Same author

Pediatric multiple sclerosis.

Neurologic clinics·2011
Same author

Switching multiple sclerosis patients with breakthrough disease to second-line therapy.

PloS one·2011
Same author

Multiple sclerosis therapies in pediatric patients with refractory multiple sclerosis.

Archives of neurology·2010
Same author

Health-related quality of life is reduced in pediatric multiple sclerosis.

Pediatric neurology·2010

Osteopontin (OPN) is a multifunctional protein involved in bone, immunity, and cancer. Its role in autoimmune diseases like multiple sclerosis highlights its potential as a therapeutic target.

Area of Science:

  • Biochemistry
  • Immunology
  • Cell Biology

Context:

  • Osteopontin (OPN), a sialylated glycoprotein, was initially identified in bone matrix.
  • OPN is a member of the SIBLING protein family, known for its RGD motif and diverse ligand interactions.
  • It functions both intracellularly and extracellularly, binding to various ligands like integrins and hydroxyapatite.

Purpose:

  • To review the structural, functional, and pathological aspects of osteopontin.
  • To discuss the osteopontin knockout phenotype in mice and its implications.
  • To highlight OPN's role in diseases and its potential as a therapeutic target.

Summary:

  • Osteopontin (OPN) is a pleiotropic glycoprotein with roles in bone mineralization inhibition, inflammation, and immune responses.

Related Experiment Videos

  • It is implicated in various pathologies, including cancer and infectious diseases.
  • Recent findings demonstrate OPN's critical involvement in T-helper 1 (TH1) mediated autoimmune diseases, such as multiple sclerosis.

    • Impact:

    • Osteopontin's diverse functions and pathological relevance make it a significant area of research.
    • Understanding OPN's role in autoimmune diseases offers potential therapeutic strategies.
    • The osteopontin knockout model provides valuable insights into its in vivo functions and disease associations.