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Is the brain hormonally imprintable?

Gyorgy Csaba1, Kornélia Tekes

  • 1Department of Genetics, Cell and Immunobiology, Semmelweis University, Nagyvarad ter 4, P.O. Box 370, Budapest H-1445, Hungary. csagyor@dgci.sote.hu

Brain & Development
|October 4, 2005
PubMed
Summary
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Hormonal imprinting during critical perinatal periods shapes lifelong receptor function. Faulty imprinting from drug exposure or stress can lead to harmful, lasting effects on the adult brain.

Area of Science:

  • Neuroendocrinology
  • Developmental neuroscience
  • Molecular psychiatry

Background:

  • Hormonal imprinting establishes receptor binding and cellular response capacity early in life.
  • This critical process occurs during the perinatal period with the initial hormone-receptor interaction.
  • Deviations, such as exposure to similar molecules or hormone imbalances, can lead to faulty imprinting with permanent consequences.

Purpose of the Study:

  • To investigate the mechanisms and consequences of hormonal imprinting.
  • To explore the impact of prenatal and neonatal exposures on brain development and adult function.
  • To discuss the potential for late imprinting and its implications for medical treatments.

Main Methods:

  • Review and synthesis of existing literary data on hormonal imprinting.

Related Experiment Videos

  • Analysis of the effects of various exogenous and endogenous molecules on imprinting.
  • Discussion of observations related to endorphin and serotonin imprinting.

    • Main Results:

    • Prenatal or neonatal exposure to opiates, drugs, or stress can negatively impact the adult brain.
    • Perinatal imprinting with endorphin or serotonin alters brain serotonin levels, sexual activity, and aggression.
    • Late imprinting, such as antagonist treatment at weaning, also affects brain serotonin content.

    Conclusions:

    • Excess endogenous molecules can trigger perinatal imprinting.
    • The brain can undergo late imprinting via receptor-level agents, including endogenous endorphins.
    • Understanding imprinting is crucial for evaluating the long-term effects of medical interventions.