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Infantile bilateral striatal necrosis associated with human herpes virus-6 (HHV-6) infection

Aki Murakami1, Masafumi Morimoto, Shinsuke Adachi

  • 1Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Horikoji, Kamigyo, Kyoto 602-8566, Japan. akkylin@koto.kpu-m.ac.jp

Brain & Development
|October 4, 2005
PubMed

Insights

This report details the first case of infantile bilateral striatal necrosis (IBSN) linked to human herpesvirus 6 (HHV-6) infection. A previously healthy infant developed neurological symptoms and striatal abnormalities after a rash illness.

Area of Science:

  • Neurology
  • Virology
  • Pediatrics

Background:

  • Infantile bilateral striatal necrosis (IBSN) is a rare neurological disorder.
  • Human herpesvirus 6 (HHV-6) is a common viral infection in young children.

Observation:

  • A 1-year-old female presented with acute neurological signs including oral dyskinesia and involuntary movements.
  • The patient had a history of exanthema subitum (rose rash).

Findings:

  • Magnetic resonance imaging (MRI) revealed abnormal signals in the bilateral striatal regions.
  • Elevated serum HHV-6 IgM antibodies confirmed active HHV-6 infection.
  • This case is the first reported instance of HHV-6 related IBSN.

Implications:

  • This finding expands the known neurological complications associated with HHV-6 infection.
  • Highlights the importance of considering HHV-6 in the differential diagnosis of acute neurological syndromes in infants.
  • Suggests a potential etiological link between HHV-6 and striatal injury in children.

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