New multiresidue analytical method dedicated to trace level measurement of brominated flame retardants in human
Ronan Cariou1, Jean-Philippe Antignac, Philippe Marchand
1LABoratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA,) Ecole Nationale Vétérinaire de Nantes, France.
Abstract:
A new method has been developed for the multi-residue measurement of the main brominated flame retardants (alpha- and gamma-hexabromocyclododecane (HBCD), tetrabromobisphenol A (TBBP-A) and polybrominated diphenyl ethers including decabromodiphenyl ether) in human biological matrices (serum, adipose tissue and breast milk). The proposed sample preparation procedure focused on reduced solvent and consumable consumption and associated procedural contamination, as well as reduced sample size. This protocol was fully validated and was proved to be suitable for identification of brominated flame retardant residues at ultra-trace level, as attested by preliminary results on real samples.
