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[Catastrophic antiphospholipid syndrome after ovulation induction]
E Chauvet1, S Canet, G Huchard
1Service de médecine interne, centre hospitalier Saint-Jean, 20, avenue du Languedoc, 66000 Perpignan, France. miquel.barcelo@wanadoo.fr
La Revue De Medecine Interne
|October 4, 2005
Summary
Ovulation induction (OI) may trigger catastrophic antiphospholipid syndrome (CAPS), a rare condition linked to antiphospholipid syndrome (APLS). Careful patient screening is vital for high-risk pregnancies undergoing OI.
Area of Science:
- Reproductive Endocrinology
- Nephrology
- Rheumatology
Background:
- Catastrophic antiphospholipid syndrome (CAPS) is a rare, severe manifestation of antiphospholipid syndrome (APLS).
- Predictive factors for CAPS development remain incompletely understood.
- Women with APLS and infertility may undergo ovulation induction (OI).
Observation:
- A patient with APLS presented with acute renal failure, hypertension, seizures, and respiratory failure post-OI.
- Immunologic tests and medical history supported an APLS diagnosis.
- Renal biopsy revealed thrombotic microangiopathy, confirming CAPS.
Findings:
- Ovulation induction (OI) is implicated as a potential trigger for CAPS in susceptible individuals.
- The patient's condition improved with supportive care, including respiratory assistance, antihypertensive treatment, and anticoagulation.
Implications:
- OI may precipitate CAPS in patients with underlying antiphospholipid syndrome (APLS).
- Pre-treatment screening of immunologic status and medical history is crucial for patients undergoing OI.
- This highlights the need for careful management of high-risk pregnancies in women with APLS.