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Related Experiment Videos

[Catastrophic antiphospholipid syndrome after ovulation induction].

E Chauvet1, S Canet, G Huchard

  • 1Service de médecine interne, centre hospitalier Saint-Jean, 20, avenue du Languedoc, 66000 Perpignan, France. miquel.barcelo@wanadoo.fr

La Revue De Medecine Interne
|October 4, 2005
PubMed
Summary

Ovulation induction (OI) may trigger catastrophic antiphospholipid syndrome (CAPS), a rare condition linked to antiphospholipid syndrome (APLS). Careful patient screening is vital for high-risk pregnancies undergoing OI.

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Area of Science:

  • Reproductive Endocrinology
  • Nephrology
  • Rheumatology

Background:

  • Catastrophic antiphospholipid syndrome (CAPS) is a rare, severe manifestation of antiphospholipid syndrome (APLS).
  • Predictive factors for CAPS development remain incompletely understood.
  • Women with APLS and infertility may undergo ovulation induction (OI).

Observation:

  • A patient with APLS presented with acute renal failure, hypertension, seizures, and respiratory failure post-OI.
  • Immunologic tests and medical history supported an APLS diagnosis.
  • Renal biopsy revealed thrombotic microangiopathy, confirming CAPS.

Findings:

  • Ovulation induction (OI) is implicated as a potential trigger for CAPS in susceptible individuals.
  • The patient's condition improved with supportive care, including respiratory assistance, antihypertensive treatment, and anticoagulation.

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Implications:

  • OI may precipitate CAPS in patients with underlying antiphospholipid syndrome (APLS).
  • Pre-treatment screening of immunologic status and medical history is crucial for patients undergoing OI.
  • This highlights the need for careful management of high-risk pregnancies in women with APLS.