Jove
Visualize
Contact Us

Related Experiment Videos

Cutaneous polyarteritis nodosa in children.

Basil M Fathalla1, Laurie Miller, Stephen Brady

  • 1Division of Pediatric Rheumatology, Tufts University/New England Medical Center, Boston, Massachusetts, USA.

Journal of the American Academy of Dermatology
|October 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Juvenile Sjögren disease: time for age-specific classification criteria.

Pediatric rheumatology online journal·2026
Same author

Corrigendum to: Sustainable livestock systems to improve human health, nutrition, and economic status.

Animal frontiers : the review magazine of animal agriculture·2025
Same author

Reply to Letter to the Editor: Childhood Familial Mediterranean Fever in the USA: Spectrum of Clinical Phenotypes and MEFV Genotypes in a Cohort From Southeast Michigan.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2025
Same author

Internationally Adopted and Migrant Children Had Important Health Issues Requiring Systematic Initial Screening at Arrival.

Acta paediatrica (Oslo, Norway : 1992)·2025
Same author

Childhood Familial Mediterranean Fever in the United States: Spectrum of Clinical Phenotypes and MEFV Genotypes in a Cohort From Southeast Michigan.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2024
Same author

Continuum: A Postdischarge Supportive Care Intervention for Hospitalized Patients With Advanced Cancer.

Journal of pain and symptom management·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

This study details four children with cutaneous polyarteritis nodosa, a vasculitis causing skin nodules and fever without organ damage. Early treatment and monitoring are key for managing this chronic childhood condition.

Area of Science:

  • Pediatric Rheumatology
  • Dermatology
  • Immunology

Background:

  • Cutaneous vasculitis in children presents diverse clinical features.
  • Cutaneous polyarteritis nodosa (cPAN) is a rare form of vasculitis affecting skin vessels.

Purpose of the Study:

  • To describe the clinical course and histopathology of pediatric cutaneous vasculitis.
  • To characterize children with tender cutaneous nodules and fever without systemic involvement.

Main Methods:

  • Retrospective chart review of four pediatric patients diagnosed with cutaneous vasculitis.
  • Analysis of clinical manifestations, laboratory findings, skin biopsy results, and treatment outcomes.

Main Results:

  • All four patients presented with tender erythematous cutaneous nodules, fever, and leukocytosis.

Related Experiment Videos

  • Skin biopsies confirmed inflammation of medium-sized cutaneous arteries, consistent with cutaneous polyarteritis nodosa.
  • Patients showed initial response to prednisone, but relapses occurred upon tapering; some required additional immunosuppressants.

    • Conclusions:

    • Pediatric cutaneous polyarteritis nodosa is a distinct entity characterized by painful nodules, fever, and lack of major organ involvement.
    • The condition often follows a chronic or recurrent course, necessitating long-term management.
    • Screening for and treating streptococcal infections may be beneficial, though not always curative.