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Gastroesophageal reflux.

Doron Zamir1

  • 1Department of Internal Medicine D, Barzilai Medical Center, Ashkelon, 78306, Israel. ZAMIR@BARZI.HEALTH.GOV.IL

European Journal of Internal Medicine
|October 4, 2005
PubMed
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Gastroesophageal reflux disease (GERD) is a common gastrointestinal issue. While proton pump inhibitors offer relief, complications like Barrett's esophagitis and esophageal cancer require further investigation.

Area of Science:

  • Gastroenterology
  • Otolaryngology

Background:

  • Gastroesophageal reflux disease (GERD) is the most prevalent gastrointestinal disorder.
  • Common symptoms include heartburn, regurgitation, and dysphagia, but otolaryngologic manifestations like chronic cough and hoarseness can also be primary signs.

Purpose of the Study:

  • To review the diagnosis and management of GERD.
  • To discuss the common complication of Barrett's esophagitis and its association with esophageal adenocarcinoma.

Main Methods:

  • Diagnostic methods include endoscopy, barium studies, pH monitoring, and therapeutic trials.
  • Pharmacological treatments involve H2 antagonists and proton pump inhibitors (PPIs).
  • Surgical options like laparoscopic fundoplication are considered for refractory cases.

Related Experiment Videos

Main Results:

  • PPIs and H2 antagonists provide symptomatic relief for most GERD patients.
  • Laparoscopic fundoplication remains an option for select patients.
  • Barrett's esophagitis is a significant complication linked to esophageal adenocarcinoma.

Conclusions:

  • GERD diagnosis relies on a combination of clinical presentation and objective tests.
  • While medical and surgical treatments manage symptoms, the prevention of complications like Barrett's esophagitis by PPIs or H2 antagonists is under ongoing research.