The problem of subepidermal blisters in neoformed integuments

The present paper is a review of articles on the onset of subepidermal blisters in neoformed integuments. Considering the discrepancy between the literature data and our clinical experience concerning spontaneous onset of subepidermal blisters in neoformed integuments, we decided to conduct an extensive review of the literature. The main finding arising from it was the lack of characterization of the neoformed integument where the blisters were formed. These were normally referred to only by clinical descriptions such as "spontaneously healed burn", "grafted site", "donor site", "epidermal graft". Anatomical and clinical pathology aspects such as the formation mechanism of these integuments and the respective tissues that comprise them were not considered. We concluded that by adopting more precise criteria to classify neoformed integuments we would realize that split thickness grafts are not susceptible to blister formation.