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Neonatal seizures associated with maternal hydroxyzine hydrochloride in late pregnancy

Raphaël Serreau1, Meriem Komiha, Florence Blanc

  • 1Paediatric Pharmacology and Pharmacogenetic, Hôpital Robert debré, 48 boulevard Sérurier, Paris, France. raphael.serreau@rdb.aphp.fr

Reproductive Toxicology (Elmsford, N.Y.)
|October 4, 2005
PubMed

This is the first report of a neonatal withdrawal syndrome associated with maternal hydroxyzine treatment (150 mg/day) confirmed by measurements of hydroxyzine plasma concentrations in the mother and infant after birth. Hydroxyzine plasma concentrations were measured by liquid chromatography-mass spectrometry. Neurological symptoms with low neonatal concentrations of hydroxyzine may be due to a withdrawal syndrome. According to previous observations and this case report, clinicians should be warned of this possible rare neurological complication of hydroxyzine in neonates born from long term treated mothers.

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