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Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder
Tristan Gorrindo1, R J R Blair, Salima Budhani
1Mood and Anxiety Program, National Institute of Mental Health, Bldg. 10, Rm. 4N-208, 10 Center Dr.-MSC 1255, Bethesda, MD 20892-1255, USA.
Objective:
Patients with bipolar disorder become hyperhedonic when manic and anhedonic when depressed; therefore, it is important to test whether patients with bipolar disorder show deficits on behavioral paradigms exploring reward/punishment mechanisms.
Method:
A probabilistic response-reversal task was administered to 24 bipolar children and 25 comparison subjects.
Results:
Patients made more errors during probabilistic reversal, took longer to learn the new reward object, and were less likely to meet the learning criterion.
Conclusions:
Children with bipolar disorder may have a reversal learning deficit.
