[Low rate of achieving LDL-cholesterol objective in a low income population]

Luciano J Vacanti1, Silvio C de Moraes Santos, Alessandro M Fujita

  • 1Instituto do Coração do Distrito Federal (InCor-DF), Distritio Federal, DF. lvacanti@cardiol.br

Insights

Low-income patients often fail to meet LDL-cholesterol goals set by Brazilian Dyslipidemia Guidelines. Very old, high-risk individuals showed significantly lower goal achievement, highlighting disparities in cardiovascular care.

Area of Science:

  • Cardiology
  • Public Health
  • Lipidology

Context:

  • Assesses adherence to the 3rd Brazilian Dyslipidemia Guidelines in a low-income population.
  • Investigates hypolipidemic therapy challenges due to irregular state supply.
  • Focuses on coronary artery disease risk stratification.

Purpose:

  • To evaluate the percentage of patients meeting dyslipidemia objectives.
  • To compare goal achievement between younger (<75) and older (≥75) high-risk patients.
  • To analyze the impact of socioeconomic factors on lipid management.

Summary:

  • 190 patients (low/middle risk: 51, high risk: 139) were analyzed; 69% had low family income (1-2 minimum salaries).
  • Among high-risk patients, only 30% achieved LDL-cholesterol targets.
  • Goal attainment was significantly lower in patients ≥75 years (16%) compared to those <75 years (30%, p=0.04).

Impact:

  • Highlights low achievement of dyslipidemia targets in a vulnerable population.
  • Identifies very old, high-risk patients as a group with significantly poorer outcomes.
  • Underscores the need for improved access to statins and tailored interventions for low-income populations.
Abstract

Related Concept Videos

Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...