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[Hyperhomocysteinemia as a risk factor for coronary atherosclerotic diseases in the elderly]

Claudia Felícia Gravina-Taddei1, Michel Batlouni, Camila Sarteschi

  • 1Instituto Dante Pazzanese de Cardiologia, São Paulo, SP. clau-gravina@hotmail.com

Arquivos Brasileiros De Cardiologia
|October 4, 2005
PubMed

Insights

High homocysteine levels (hyperhomocysteinemia) are an independent risk factor for coronary artery disease in elderly individuals. This finding highlights a significant link between elevated homocysteine and cardiovascular risk in older populations.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry
  • Geriatrics

Context:

  • Atherosclerotic disease poses a significant health challenge in elderly populations.
  • Understanding modifiable risk factors is crucial for preventative strategies in aging individuals.

Purpose:

  • To determine if hyperhomocysteinemia is an independent risk factor for atherosclerotic disease in the elderly.
  • To quantify the association between homocysteine levels and coronary artery disease risk in this demographic.

Summary:

  • A case-control study involving 172 elderly individuals (84 cases, 88 controls) assessed homocysteine levels.
  • Multivariate analysis revealed hyperhomocysteinemia as an independent risk factor for coronary artery disease (CAD) in the elderly.
  • Elevated homocysteine levels were significantly associated with increased CAD risk, with a risk rate of 2.03 for hyperhomocysteinemia.

Impact:

  • Identifies hyperhomocysteinemia as a key, independent risk factor for CAD in the elderly.
  • Suggests potential therapeutic targets for reducing cardiovascular risk in older adults.
  • Emphasizes the importance of monitoring homocysteine levels in geriatric cardiovascular risk assessments.
Abstract

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