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Related Experiment Video

Updated: Jan 25, 2026

Metabolic Support of Excised, Living Brain Tissues During Magnetic Resonance Microscopy Acquisition

Metabolic Support of Excised, Living Brain Tissues During Magnetic Resonance Microscopy Acquisition

Published on: October 18, 2017

Magnetization transfer effect on human brain metabolites and macromolecules.

Mary A McLean¹, Robert J Simister, Gareth J Barker

¹MRI Unit, National Society for Epilepsy, Bucks, UK. m.mclean@ion.cl.ac.uk

Magnetic Resonance in Medicine

|October 4, 2005

Summary

Magnetization transfer (MT) effects on brain metabolites and water were measured in vivo. Significant MT saturation was observed for N-acetylated compounds, choline, myo-inositol, and lactate.

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Area of Science:

Neuroimaging
Biophysics

Background:

Magnetization transfer (MT) is a biophysical process that can be used to probe molecular interactions.
Understanding MT effects on brain metabolites and water is crucial for accurate in vivo spectroscopy.

Purpose of the Study:

To quantify the in vivo Magnetization Transfer (MT) effect on metabolites, water, and macromolecules in the human frontal lobe at 1.5 Tesla.
To assess the specificity of MT pulses and their impact on metabolite signals.

Main Methods:

Implementation of a novel pulse sequence combining hard pulses with Point-Resolved Spectroscopy (PRESS).
Application of MT pulses at frequency offsets of 2500 Hz or 30 kHz.
Acquisition parameters: echo time (TE) of 30 ms, repetition time (TR) of 3 s.

Main Results:

An in vivo MT effect of 46% was observed on water signals.
Direct saturation by MT pulses was confirmed to be under 4% for all measured metabolites.
Significant MT saturation was observed for N-acetylated compounds, choline (Cho), myo-inositol, and lactate (Lac).
A trend of MT effect was noted for glutamate + glutamine (Glx), and the expected effect on creatine (Cr).
No significant MT effect was detected on the macromolecule signal.

Conclusions:

The implemented pulse sequence effectively quantifies in vivo MT effects on brain metabolites and water.
Specific metabolites like Cho, myo-inositol, and Lac show significant MT saturation.
The findings contribute to improved interpretation of in vivo magnetic resonance spectroscopy data.