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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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On the dark rim artifact in dynamic contrast-enhanced MRI myocardial perfusion studies

E V R Di Bella1, D L Parker, A J Sinusas

  • 1Department of Radiology, University of Utah, Salt Lake City, Utah 84108, USA. Ed@ucair.med.utah.edu

Magnetic Resonance in Medicine
|October 4, 2005
PubMed

Insights

Dark rim artifacts in cardiac MRI are often attributed to gadolinium, motion, or resolution. This study demonstrates that resolution effects alone can cause these dark rims in myocardial perfusion imaging.

Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Medical Physics

Background:

  • Dynamic contrast-enhanced (DCE) MRI perfusion studies can exhibit a dark rim artifact.
  • This artifact appears along the subendocardial border of the left ventricle (LV) and myocardium.
  • Previous hypotheses attributed this artifact to susceptibility effects, motion, or resolution.

Purpose of the Study:

  • To investigate the cause of dark rim artifacts in cardiac MRI.
  • To determine if resolution effects alone can produce dark rim artifacts.
  • To differentiate artifact causes in myocardial perfusion imaging.

Main Methods:

  • Utilized motionless ex vivo human hearts.
  • Filled the cardiac cavities with a gadolinium-based contrast agent.
  • Performed dynamic contrast-enhanced MRI perfusion studies on the prepared specimens.

Main Results:

  • Demonstrated that dark rim artifacts can be consistently reproduced.
  • Showed that these artifacts are solely attributable to image resolution effects.
  • Ruled out susceptibility or motion as necessary factors for dark rim formation.

Conclusions:

  • Resolution effects are a significant factor in the formation of dark rim artifacts in cardiac MRI.
  • The findings help refine the interpretation of myocardial perfusion imaging.
  • This research clarifies artifact origins, improving diagnostic accuracy in cardiovascular MRI.

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